Acute effects of the endovenous application of the royal mushroom (Agaricus blazei Murill) on mean arterial pressure and heart rate of anesthetized rats.

The aim of this paper was to verify the acute effects of the endovenous application of the aqueous extract of Agaricus blazei Murill on mean arterial pressure and heart rate of the anesthetized rats. The injected concentrations were: 1.25 mg/kg, 2.50 mg/kg and 5.00 mg/kg, in volume of 0.2 mL. The rats were anesthetized with sodium thiopental and, after tracheotomy, both jugular vein and carotid artery were cannulated. The MAP was recorded with a Biopac System, model MP100. The HR was obtained with an electrocardiograph model ECG-4 (Funbec). The records were made in the control and 15, 30, 45, 60 and 120s after the application of the different concentrations of the extracts. The values were expressed by mean ± SEM and by paired “t”-Student-Newman-Keuls and Tukey tests (p<0.05). The aqueous extract of the A. blazei decreased the MAP of dependent manner. The concentration of 1.25 mg/kg did not provoke effects; 2.50 mg/kg provoked decrease of the PAM at 15s (p<0.01) and of the HR at 30s (p<0.001) and 5.00 mg/kg provoked decrease of the PAM at 15s (p<0.001) and of the HR at 15 and 30s (p<0.001).

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