Hiperglucemia

Protocolo

 

La hiperglucemia significa cantidad o concentración excesiva de glucosa en sangre.

La glucosa viaja por el torrente sanguíneo como moneda de cambio energético para el organismo. El catabolismo de la glucosa se traduce en energía útil celular.

La cantidad de glucosa en sangre puede ser elevada bien por la síntesis elevada de glucosa o bien porque no es retirada correctamente del torrente sanguíneo para ser catabolizada por la célula.

En la mayoría de los casos la hiperglucemia está relacionada con diabetes, sin embargo una persona no diabética puede presentar niveles elevados de glucosa en sangre. Si bien es cierto que si la hiperglucemia resulta un síntoma propio de la diabetes una hiperglucemia tiende a concluir en una enfermedad diabética.

Mediante Micoterapia Champiñón del Sol, Maitake y Coprinus comatus son los hongos utilizados con mayor éxito para disminuir la concentración de glucosa en sangre.

Coprinus comatus es conocido por tratarse de un hongo rico en Vanadio, CCRV (C.comatus rico en Vanadio). Diferentes grupos de investigación ha estudiado el efecto de CCRV sobre el metabolismo de la glucosa concluyendo que su ingesta disminuye los niveles de glucemia así como la concentración de hemoglobina glucosilada en sangre.

La fracción polisacárida del Maitake incrementa el metabolismo de la glucosa por disminución de resistencia a la insulina, favoreciendo la entrada de la glucosa al espacio intracelular, evitando su transformación engrasa por el hígado y los adipocitos.

Los recientes estudios del Dr. C.H. Hsu y sus colegas demostraron que el extracto de Champiñón del Sol estimula los adipocitos para que incrementen su producción de adiponectina, la que disminuye la resistencia celular a la insulina, favoreciendo la catabolización de la glucosa y su consiguiente disminución en sangre.

Coprinus-HdT es el resultado de una compleja formulación en la que se combinan en diferentes proporciones de Maitake, Champiñón del Sol y Corpinus comatus junto con otros compuestos antiglucemiantes como glucomanano, nopal, y cromo como elemento traza esencial

Protocolo:

Askorbato k-HdTPowered + Coprinus comatus-HdT

El Askorbato k-HdTPowered debe preceder a la toma del resto de los hongos.

En ayunas, toma una cápsula de Ascorbato k-HdT y a los cinco minutos una cápsula de Coprinus comatus-HdT.

 

Tomas Mañana Mediodía Noche
Askorbato k- HdTPowered 1 1 1 Biodisponibilidad
Coprinus-HdT 1 1 1 Hipoglucemiante y reductor de la resistencia a la insulina

 

Duración del tratamiento: Mínimo seis meses.

 El protocolo clínico expuesto está basado en las recomendaciones generales estipuladas por elmInstituto Internacional de Micoterapia (IMI) y deberá ser consultado por cada profesional para el uso de complementos elaborados a base de extractos de hongos. Será responsabilidad del facultativo variar la prescripción y la posología en función de su criterio médico así como de los síntomas y signos clínicos de cada paciente.

 

C.H. Hsu, Y.L. Liao, S.C. Lin, K.C. Hwang and P. Chou (2007) The Mushroom Agaricus blazei Murill in Combination with Metformin and Gliclazide Improves Insulin Resistance in Type 2 Diabetes: A Randomized, Double-Blinded and Placebo-Controlled Clinical Trial. Jour. Altern. and Complementary Med.. 13 (1): 97–102.

Referencias


Title/Título: Oral vanadyl sulfate improves hepatic and peripheral insulin sensitivity in patients with Non-Insulin- dependent Diabetes Mellitus

Author(s)/Autor(es): Cohen N., Halberstan M., Shlimovich P., Chang C., Shamoon H., Rossetti L.. Oral vanadyl sulfate improves hepatic and peripheral insulin sensitivity in patients with Non-Insulin- dependent Diabetes Mellitus. Department of Medicine and the Diabetes Research Center, Albert Einstein College of Medicine, New York 10461

Abstract/Resumen: We examined the in vivo metabolic effects of vanadyl sulfate (VS) in non-insulin-dependent diabetes mellitus (NIDDM). Six NIDDM subjects treated with diet and/or sulfonylureas were examined at the end of three consecutive periods: placebo for 2 wk, VS (100 mg/d) for 3 wk, and placebo for 2 wk. Euglycemic hyperinsulinemic (30 mU/m2.min) clamps and oral glucose tolerance tests were performed at the end of each study period. Glycemic control at baseline was poor (fasting plasma glucose 210 +/- 19 mg/dl; HbA1c 9.6 +/- 0.6%) and improved after treatment (181 +/- 14 mg/dl [P < 0.05], 8.8 +/- 0.6%, [P < 0.002]); fasting and post-glucose tolerance test plasma insulin concentrations were unchanged. After VS, the glucose infusion rate during the clamp was increased (by approximately 88%, from 1.80 to 3.38 mg/kg.min, P < 0.0001). This improvement was due to both enhanced insulin-mediated stimulation of glucose uptake (rate of glucose disposal [Rd], +0.89 mg/kg.min) and increased inhibition of HGP (-0.74 mg/kg.min) (P < 0.0001 for both). Increased insulin-stimulated glycogen synthesis (+0.74 mg/kg.min, P < 0.0003) accounted for > 80% of the increased Rd after VS, and the improvement in insulin sensitivity was maintained after the second placebo period. The Km of skeletal muscle glycogen synthase was lowered by approximately 30% after VS treatment (P < 0.05). These results indicate that 3 wk of treatment with VS improves hepatic and peripheral insulin sensitivity in insulin-resistant NIDDM humans. These effects were sustained for up to 2 wk after discontinuation of VS.

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Title/Título: A comparison of hypoglycemic activity of three species of basidiomycetes rich in vanadium

Author(s)/Autor(es): Han C, Liu T.. A comparison of hypoglycemic activity of three species of basidiomycetes rich in vanadium. School of Pharmacy, Shandong University of Traditional Chinese Medicine, Jinan, 250355.

Abstract/Resumen: The hypoglycemic activity of fermented mushroom of three fungi of basidiomycetes rich in vanadium was studied in this paper. Alloxan- and adrenalin-induced hyperglycemic mice were used in the study. The blood glucose and the sugar tolerance were determined. After the mice were administered (ig) with Coprinus comatus rich in vanadium, the blood glucose of alloxan-induced hyperglycemic mice decreased (p < 0.05), ascension of blood glucose induced by adrenalin was inhibited (p < 0.01) and the sugar tolerance of the normal mice was improved. However, the same result did not occur in Ganoderma lucidum and Grifola frondosa group. Compared with Ganoderma rich in vanadium and Grifola frondosa rich in vanadium, the hypoglycemic effects of Coprinus comatus rich in vanadium on hyperglycemic animals are significant; it may be used as a hypoglycemic food or medicine for hyperglycemic people.

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Title/Título: Comparison of vanadium-rich activity of three species fungi of basidiomycetes

Author(s)/Autor(es): Han C, Cui B, Qu J. Comparison of vanadium-rich activity of three species fungi of basidiomycetes. School of Pharmacy, Shandong University of Traditional Chinese Medicine, Jinan 250355.

Abstract/Resumen: A comparison of vanadium-rich activity of three species fungi of Basidiomycetes, Ganoderma lucidum, Coprinus comatus, and Grifola frondosa, was studied. By fermentation and atomic absorption spectroscopy analysis, the biomass of G. lucidum and G. frondosa declined rapidly when the concentration of vanadium exceeded 0.3% but the biomass of C. comatus did not decline rapidly until the concentration of vanadium exceeded 0.4% and the content of vanadium accumulated in the mycelia was 3529.3 microg/g. After the mice were administered (intragastrically) with vanadium-rich C. comatus, the blood glucose of alloxan-induced hyperglycemic mice was decreased (p < 0.05) and the body weight of the alloxan-induced hyperglycemic mice was increased gradually. Thus, we selected C. comatus to absorb vanadium and chose 0.4% as the optimal concentration of vanadium for the pharmacological works.

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Title/Título: Hypoglycemic activity of fermented mushroom of Coprinus comatus rich in vanadium

Author(s)/Autor(es): Han C., Yuan J., Wang Y., Li L.. Hypoglycemic activity of fermented mushroom of Coprinus comatus rich in vanadium. School of Pharmacy, Shandong University of Traditional Chinese Medicine, Jinan 250014, PR China.

Abstract/Resumen: The hypoglycemic activity of fermented mushroom of Coprinus comatus rich in vanadium (CCRV) was studied in this paper. Alloxan and adrenalin induced hyperglycemic mice were used in the study. The blood glucose and the HbA1c of the mice were analyzed, respectively. At the same time, the sugar tolerance of the normal mice was also determined. After the mice were administered (ig) with CCRV, the blood glucose and the HbA1c of alloxan-induced hyperglycemic mice decreased (p < 0.05, p < 0.01), ascension of blood glucose induced by adrenalin was inhibited (p < 0.01) and the sugar tolerance of the normal mice was improved. Also, the body weight of the alloxan-induced hyperglycemic mice was increased gradually. In the fermented mushroom of C. comatus, vanadium at lower doses in combination with C. comatus, induced significant decreases of the blood glucose and HbA1c levels in hyperglycemic mice.

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Title/Título: Comparison of Hypoglycemic Activity of Trace Elements Absorbed in Fermented Mushroom of Coprinus comatus

Author(s)/Autor(es): Lv Y, Han L, Yuan C, Guo J. Comparison of Hypoglycemic Activity of Trace Elements Absorbed in Fermented Mushroom of Coprinus comatus.College of Chemical Engineering, Qingdao University of Science and Technology, Qingdao, 266042,

Abstract/Resumen: The effect of fermented mushroom of Coprinus comatus rich in trace elements, including vanadium, chromium, zinc, magnesium, copper, iron, and nickel, on glycemic metabolism was studied in this paper. Alloxan-induced hyperglycemic mice were used in the study. The blood glucose, glycohemoglobin, and glycogen synthesis of the mice were analyzed, respectively. At the same time, the gluconeogenesis of the normal mice was also determined. After the mice were administered (ig) with C. comatus rich in vanadium (CCRV), the blood glucose and the glycohemoglobin of alloxan-induced hyperglycemic mice decreased (p < 0.05, p < 0.01), glycogen synthesis of alloxan-induced hyperglycemic mice elevated (p < 0.01), the gluconeogenesis of the normal mice was inhibited (p < 0.01), and the sugar tolerance of the normal mice was improved. However, the same result did not occur in other groups. Vanadium at lower doses in combination with C. comatus induced significant effect on glycemic metabolism in mice.

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Title/Título: Vanadium Uptake by Biomass of Coprinus comatus and Their Effect on Hyperglycemic Mice

Author(s)/Autor(es): Han C., Cui B.,Wang Y. Vanadium Uptake by Biomass of Coprinus comatus and Their Effect on Hyperglycemic Mice. Published online: 18 March 2008

Abstract/Resumen: The Vanadium uptake by Coprinus comatus and their co-effect on hyperglycemic mice were studied. By fermentation and AAS analysis, the optimal concentration of vanadium in medium was 0.4%, and the content of vanadium accumulated in the mycelia was 3,528.0 μg/g. At the concentration of 0.4%, the vanadium-associated toxicity was reduced, and its anti-diabetic effects were maintained.

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Title/Título: Comparison of Hypoglycemic Activity and Toxicity of Vanadium (IV) and Vanadium (V) Absorbed in Fermented Mushroom of Coprinus comatus

Author(s)/Autor(es): a Z, Fu Q. Comparison of Hypoglycemic Activity and Toxicity of Vanadium (IV) and Vanadium (V) Absorbed in Fermented Mushroom of Coprinus comatus. Department of Orthopaedics, Sheng Jing Hospital, China Medical University, Shenyang, 110004, People’s Republic of China.

Abstract/Resumen: This study was designed to evaluate the effect and toxicity of administration of vanadium (IV, V) absorbed by Coprinus comatus (VACC) on alloxan-induced and sucrose-fed hyperglycemic mice, respectively. The blood glucose, lipid profile, and the organ masses of the mice were analyzed. After the mice were administered with VACC, the blood glucose and the lipid profile of hyperglycemic mice decreased, irrespective of the VACC produced by vanadium (IV) or vanadium (V). However, the organ masses of the mice were significantly different after the mice were treated with vanadium (IV) and vanadium (V) 9 weeks later. The results indicate both vanadium (IV) and vanadium (V) absorbed in C. comatus have hypoglycemic activity on hyperglycemic mice. However, vanadium (IV) absorbed in C. comatus is less toxic to mice than vanadium (V).

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Title/Título: The Co-effect of Vanadium and Fermented Mushroom of Coprinus comatus on Glycaemic Metabolism

Author(s)/Autor(es): Zhou G, Han C. The Co-effect of Vanadium and Fermented Mushroom of Coprinus comatus on Glycaemic Metabolism. Biol Trace Elem Res (2008) 124:20–27.

Abstract/Resumen: The effect of fermented mushroom of Coprinus comatus rich in vanadium (CCRV) on glycaemic metabolism was studied in this paper. Alloxan-induced hyperglycemic mice were used in this study. The insulin secretion and glycogen synthesis of the mice were analyzed. At the same time, the gluconeogenesis of the normal mice was also determined. The alloxan-damaged pancreatic β-cells of the mice were also studied in this paper. After the mice were administered (i.g.) with CCRV, the level of insulin secretion and glycogen synthesis of alloxan-induced hyperglycemic mice elevated (p < 0.05, p < 0.01) and the gluconeogenesis of the normal mice was inhibited (p < 0.01). Also, the alloxan-damaged pancreatic β-cells of the mice were partly recovered gradually after the mice were administered (i.g.) with CCRV 15 days later. These may account for the causes of CCRV-induced significant decreases of the blood glucose in hyperglycemic mice.

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